Drug interactions
Deflazacort + Fosinopril-hydrochlorothiazide
Severity: Moderate
Deflazacort and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid with some mineralocorticoid activity and, like hydrochlorothiazide, can promote potassium loss. Together they raise the risk of hypokalemia, and corticosteroids may also reduce the antihypertensive effect through fluid retention.
What this interaction means in plain words
Deflazacort and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting, with corticosteroid-related sodium and fluid retention opposing antihypertensive effect.
What to do
Monitor serum potassium and blood pressure regularly and replace potassium as needed. Reassess antihypertensive dosing if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Deflazacort and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a corticosteroid with some mineralocorticoid activity and, like hydrochlorothiazide, can promote potassium loss. Together they raise the risk of hypokalemia, and corticosteroids may also reduce the antihypertensive effect through fluid retention.
How serious is the interaction between Deflazacort and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure regularly and replace potassium as needed. Reassess antihypertensive dosing if blood pressure rises.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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