Drug interactions
Deflazacort + Hydrochlorothiazide-losartan
Severity: Moderate
Deflazacort and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a corticosteroid with mineralocorticoid activity that causes potassium loss, and combined with hydrochlorothiazide it may produce additive hypokalemia. Fluid retention from the steroid can also oppose blood pressure control.
What this interaction means in plain words
Deflazacort and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from corticosteroid and thiazide effects, with steroid-related sodium retention.
What to do
Monitor serum potassium and blood pressure, and supplement potassium if needed. Losartan may partly offset potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Deflazacort and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a corticosteroid with mineralocorticoid activity that causes potassium loss, and combined with hydrochlorothiazide it may produce additive hypokalemia. Fluid retention from the steroid can also oppose blood pressure control.
How serious is the interaction between Deflazacort and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and supplement potassium if needed. Losartan may partly offset potassium loss.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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