Drug interactions
Deflazacort + Imatinib
Severity: Moderate
Deflazacort and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4, which forms the active metabolite of deflazacort. Exposure to the active metabolite rises, increasing corticosteroid adverse effects such as Cushingoid features, infection risk and adrenal suppression.
What this interaction means in plain words
Deflazacort and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibition of CYP3A4 reduces clearance of deflazacort's active metabolite.
What to do
Reduce deflazacort to about one-third of the usual dose when given with a moderate CYP3A4 inhibitor, as labeled. Monitor for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Imatinib?
MediHelp rates the interaction as moderate. Deflazacort and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4, which forms the active metabolite of deflazacort. Exposure to the active metabolite rises, increasing corticosteroid adverse effects such as Cushingoid features, infection risk and adrenal suppression.
How serious is the interaction between Deflazacort and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce deflazacort to about one-third of the usual dose when given with a moderate CYP3A4 inhibitor, as labeled. Monitor for corticosteroid toxicity.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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