Drug interactions
Deflazacort + Ipratropium-salbutamol
Severity: Moderate
Deflazacort and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salbutamol shifts potassium into cells, and deflazacort, a corticosteroid, can increase renal potassium loss. Together they may cause hypokalemia, which is more likely with high or repeated salbutamol doses and in acute asthma.
What this interaction means in plain words
Deflazacort and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive lowering of serum potassium through beta-2 mediated cellular uptake and corticosteroid mineralocorticoid-related renal potassium wasting.
What to do
Monitor serum potassium in patients on high-dose or frequent salbutamol, especially with other potassium-lowering drugs. Replace potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Deflazacort and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salbutamol shifts potassium into cells, and deflazacort, a corticosteroid, can increase renal potassium loss. Together they may cause hypokalemia, which is more likely with high or repeated salbutamol doses and in acute asthma.
How serious is the interaction between Deflazacort and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on high-dose or frequent salbutamol, especially with other potassium-lowering drugs. Replace potassium if levels fall.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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