Drug interactions
Deflazacort + Lapatinib
Severity: Moderate
Deflazacort and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase exposure to deflazacort's active metabolite. This may result in corticosteroid adverse effects such as Cushingoid features, infection and glucose elevation.
What this interaction means in plain words
Deflazacort and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4 and P-glycoprotein, increasing deflazacort active metabolite levels.
What to do
Reduce the deflazacort dose to about one-third of the usual dose while lapatinib is coadministered, per labeling for CYP3A4 inhibitors. Monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Lapatinib?
MediHelp rates the interaction as moderate. Deflazacort and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase exposure to deflazacort's active metabolite. This may result in corticosteroid adverse effects such as Cushingoid features, infection and glucose elevation.
How serious is the interaction between Deflazacort and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to about one-third of the usual dose while lapatinib is coadministered, per labeling for CYP3A4 inhibitors. Monitor for corticosteroid adverse effects.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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