Drug interactions
Deflazacort + Linagliptin-metformin
Severity: Moderate
Deflazacort and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid and can raise blood glucose by increasing insulin resistance and hepatic glucose output. This may reduce the effectiveness of metformin and linagliptin.
What this interaction means in plain words
Deflazacort and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Linagliptin-metformin belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased gluconeogenesis oppose antidiabetic effect.
What to do
Monitor blood glucose when deflazacort is started or the dose changed, and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Deflazacort and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid and can raise blood glucose by increasing insulin resistance and hepatic glucose output. This may reduce the effectiveness of metformin and linagliptin.
How serious is the interaction between Deflazacort and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when deflazacort is started or the dose changed, and intensify antidiabetic therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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