Drug interactions
Deflazacort + Mesalamine
Severity: Minor
Deflazacort and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids are said to increase renal clearance of salicylates, which could slightly lower mesalamine levels. The effect is not established for mesalamine, and they are often co-prescribed for colitis, so it is not clinically relevant.
What this interaction means in plain words
Deflazacort and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Corticosteroids may increase renal clearance of salicylate; effect on mesalamine is theoretical.
What to do
No adjustment is needed. Monitor disease control, especially when tapering the steroid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Mesalamine?
MediHelp rates the interaction as minor. Deflazacort and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids are said to increase renal clearance of salicylates, which could slightly lower mesalamine levels. The effect is not established for mesalamine, and they are often co-prescribed for colitis, so it is not clinically relevant.
How serious is the interaction between Deflazacort and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor disease control, especially when tapering the steroid.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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