Drug interactions
Deflazacort + Nicardipine
Severity: Moderate
Deflazacort and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak-to-moderate CYP3A4 inhibitor and P-glycoprotein inhibitor and may raise exposure to the active metabolite of deflazacort. This can increase corticosteroid adverse effects such as fluid retention, hyperglycemia and infection risk.
What this interaction means in plain words
Deflazacort and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of deflazacort's active metabolite by nicardipine.
What to do
Monitor for corticosteroid adverse effects. Deflazacort labeling advises reducing the dose to one-third with moderate or strong CYP3A4 inhibitors, so consider dose reduction if inhibition is clinically significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Nicardipine?
MediHelp rates the interaction as moderate. Deflazacort and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a weak-to-moderate CYP3A4 inhibitor and P-glycoprotein inhibitor and may raise exposure to the active metabolite of deflazacort. This can increase corticosteroid adverse effects such as fluid retention, hyperglycemia and infection risk.
How serious is the interaction between Deflazacort and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects. Deflazacort labeling advises reducing the dose to one-third with moderate or strong CYP3A4 inhibitors, so consider dose reduction if inhibition is clinically significant.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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