Drug interactions
Deflazacort + Sertraline
Severity: Minor
Deflazacort and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort's active metabolite is cleared via CYP3A4, and strong or moderate inhibitors increase exposure. Sertraline is only a weak CYP3A4 inhibitor, so any increase is likely small.
What this interaction means in plain words
Deflazacort and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly reduce deflazacort metabolite clearance.
What to do
No empirical dose change is generally needed; monitor for corticosteroid adverse effects such as fluid retention, hyperglycemia or infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Sertraline?
MediHelp rates the interaction as minor. Deflazacort and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deflazacort's active metabolite is cleared via CYP3A4, and strong or moderate inhibitors increase exposure. Sertraline is only a weak CYP3A4 inhibitor, so any increase is likely small.
How serious is the interaction between Deflazacort and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally needed; monitor for corticosteroid adverse effects such as fluid retention, hyperglycemia or infection.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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