Drug interactions
Deflazacort + Sitagliptin
Severity: Minor
Deflazacort and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort, a glucocorticoid, can raise blood glucose and counteract the effect of sitagliptin. Glycemic control may deteriorate during corticosteroid therapy, especially at higher doses or longer duration.
What this interaction means in plain words
Deflazacort and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Sitagliptin belongs to Endocrine.
Why it happens
Glucocorticoids increase gluconeogenesis and insulin resistance, opposing the antihyperglycemic effect of sitagliptin.
What to do
Monitor blood glucose during and after deflazacort therapy. Intensify the antidiabetic regimen if needed and readjust when the steroid is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Sitagliptin?
MediHelp rates the interaction as minor. Deflazacort and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deflazacort, a glucocorticoid, can raise blood glucose and counteract the effect of sitagliptin. Glycemic control may deteriorate during corticosteroid therapy, especially at higher doses or longer duration.
How serious is the interaction between Deflazacort and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after deflazacort therapy. Intensify the antidiabetic regimen if needed and readjust when the steroid is reduced.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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