Drug interactions
Deflazacort + Sodium polystyrene sulfonate
Severity: Moderate
Deflazacort and Sodium polystyrene sulfonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium polystyrene sulfonate removes potassium through the gut and corticosteroids increase renal potassium excretion, so hypokalemia may be more pronounced. Sodium load from the resin may also add to corticosteroid-related fluid retention.
What this interaction means in plain words
Deflazacort and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Sodium polystyrene sulfonate belongs to Miscellaneous.
Why it happens
Additive potassium lowering through cation exchange in the colon and corticosteroid-induced kaliuresis.
What to do
Monitor serum potassium regularly and stop or reduce the resin when potassium approaches the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Sodium polystyrene sulfonate
- Meloxicam + Sodium polystyrene sulfonate Major
- Sodium polystyrene sulfonate + Sorbitol Major
- Calcium carbonate + Sodium polystyrene sulfonate Moderate
- Levothyroxine + Sodium polystyrene sulfonate Moderate
- Lithium + Sodium polystyrene sulfonate Moderate
- Magnesium citrate + Sodium polystyrene sulfonate Moderate
Frequently asked questions
Can I take Deflazacort with Sodium polystyrene sulfonate?
MediHelp rates the interaction as moderate. Deflazacort and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate removes potassium through the gut and corticosteroids increase renal potassium excretion, so hypokalemia may be more pronounced. Sodium load from the resin may also add to corticosteroid-related fluid retention.
How serious is the interaction between Deflazacort and Sodium polystyrene sulfonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and stop or reduce the resin when potassium approaches the normal range.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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