Drug interactions
Deflazacort + Sulindac
Severity: Moderate
Deflazacort and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID use raises the risk of peptic ulceration and gastrointestinal bleeding above that of either drug alone. The risk is greater in older patients and with higher doses or longer duration.
What this interaction means in plain words
Deflazacort and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Sulindac belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury: NSAID prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Use a proton pump inhibitor for gastroprotection when co-prescribing and keep the duration short. Watch for dyspepsia, melena or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Sulindac?
MediHelp rates the interaction as moderate. Deflazacort and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID use raises the risk of peptic ulceration and gastrointestinal bleeding above that of either drug alone. The risk is greater in older patients and with higher doses or longer duration.
How serious is the interaction between Deflazacort and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a proton pump inhibitor for gastroprotection when co-prescribing and keep the duration short. Watch for dyspepsia, melena or anemia.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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