Drug interactions
Deflazacort + Tolbutamide
Severity: Moderate
Deflazacort and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that can raise blood glucose and so oppose the effect of tolbutamide. Glycemic control may worsen, especially with higher doses or prolonged use.
What this interaction means in plain words
Deflazacort and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Tolbutamide belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output antagonize sulfonylurea action.
What to do
Monitor blood glucose during corticosteroid therapy and increase tolbutamide or adjust therapy as needed. Reduce the dose again when the steroid is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Tolbutamide?
MediHelp rates the interaction as moderate. Deflazacort and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that can raise blood glucose and so oppose the effect of tolbutamide. Glycemic control may worsen, especially with higher doses or prolonged use.
How serious is the interaction between Deflazacort and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and increase tolbutamide or adjust therapy as needed. Reduce the dose again when the steroid is withdrawn.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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