Drug interactions
Deflazacort + Tolfenamic acid
Severity: Moderate
Deflazacort and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID raises the risk of peptic ulceration and gastrointestinal bleeding. Risk is greater in older patients, with high doses or with prolonged use.
What this interaction means in plain words
Deflazacort and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal damage from NSAID prostaglandin inhibition and corticosteroid effects on mucosal defense.
What to do
Limit dose and duration and consider gastroprotection with a proton pump inhibitor in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Deflazacort with Tolfenamic acid?
MediHelp rates the interaction as moderate. Deflazacort and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID raises the risk of peptic ulceration and gastrointestinal bleeding. Risk is greater in older patients, with high doses or with prolonged use.
How serious is the interaction between Deflazacort and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit dose and duration and consider gastroprotection with a proton pump inhibitor in at-risk patients.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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