Drug interactions
Deflazacort + Zafirlukast
Severity: Minor
Deflazacort and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is a weak CYP3A4 inhibitor and might slightly raise exposure to deflazacort's active metabolite. The effect is expected to be much smaller than with the moderate or strong inhibitors that prompt dose reduction.
What this interaction means in plain words
Deflazacort and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4 by zafirlukast may reduce clearance of deflazacort's active metabolite.
What to do
No dose reduction is required; monitor for corticosteroid adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Zafirlukast?
MediHelp rates the interaction as minor. Deflazacort and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast is a weak CYP3A4 inhibitor and might slightly raise exposure to deflazacort's active metabolite. The effect is expected to be much smaller than with the moderate or strong inhibitors that prompt dose reduction.
How serious is the interaction between Deflazacort and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose reduction is required; monitor for corticosteroid adverse effects during prolonged co-therapy.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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