Drug interactions
Degarelix + Fluoxetine
Severity: Moderate
Degarelix and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, like other androgen deprivation therapy, can lengthen the QT interval, and fluoxetine may add to this effect. The combination may raise the risk of arrhythmia in patients with additional cardiac risk factors.
What this interaction means in plain words
Degarelix and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization while fluoxetine blocks cardiac ion channels.
What to do
Review baseline cardiac risk and obtain an ECG before starting, then monitor periodically. Correct electrolyte abnormalities and reassess the need for both drugs if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Fluoxetine?
MediHelp rates the interaction as moderate. Degarelix and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, like other androgen deprivation therapy, can lengthen the QT interval, and fluoxetine may add to this effect. The combination may raise the risk of arrhythmia in patients with additional cardiac risk factors.
How serious is the interaction between Degarelix and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline cardiac risk and obtain an ECG before starting, then monitor periodically. Correct electrolyte abnormalities and reassess the need for both drugs if QTc becomes prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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