Drug interactions
Degarelix + Fluticasone-vilanterol
Severity: Moderate
Degarelix and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, like other androgen deprivation therapy, may prolong the QT interval, and vilanterol may add tachycardia and hypokalemia. The additive effect is likely small but relevant in patients with cardiac risk factors.
What this interaction means in plain words
Degarelix and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-2 agonist sympathetic stimulation and hypokalemia.
What to do
Check baseline ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Monitor for palpitations and syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Degarelix and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, like other androgen deprivation therapy, may prolong the QT interval, and vilanterol may add tachycardia and hypokalemia. The additive effect is likely small but relevant in patients with cardiac risk factors.
How serious is the interaction between Degarelix and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Monitor for palpitations and syncope.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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