Drug interactions
Degarelix + Lapatinib
Severity: Moderate
Degarelix and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combination raises the risk of QT prolongation and torsades de pointes. Risk is greater with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Degarelix and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and monitor QTc periodically. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Lapatinib?
MediHelp rates the interaction as moderate. Degarelix and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combination raises the risk of QT prolongation and torsades de pointes. Risk is greater with electrolyte disturbances or cardiac disease.
How serious is the interaction between Degarelix and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically. Correct potassium and magnesium abnormalities.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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