Drug interactions
Degarelix + Levofloxacin
Severity: Moderate
Degarelix and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can lengthen the QT interval, and levofloxacin may add to this effect. The combination increases the potential for torsades de pointes, especially in patients with existing cardiac risk factors.
What this interaction means in plain words
Degarelix and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with androgen deprivation altering cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and consider a non-QT-prolonging antibiotic. Monitor the QTc if levofloxacin is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Levofloxacin?
MediHelp rates the interaction as moderate. Degarelix and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can lengthen the QT interval, and levofloxacin may add to this effect. The combination increases the potential for torsades de pointes, especially in patients with existing cardiac risk factors.
How serious is the interaction between Degarelix and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and consider a non-QT-prolonging antibiotic. Monitor the QTc if levofloxacin is needed.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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