Drug interactions
Degarelix + Maprotiline
Severity: Moderate
Degarelix and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and maprotiline may also affect cardiac repolarization. Combined use may add to the risk of ventricular arrhythmia, especially in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Degarelix and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with degarelix effect attributed to androgen suppression and maprotiline to ion channel blockade.
What to do
Check an ECG and electrolytes before starting and periodically afterward, particularly in patients with other QT risk factors. Consider alternatives if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Maprotiline?
MediHelp rates the interaction as moderate. Degarelix and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and maprotiline may also affect cardiac repolarization. Combined use may add to the risk of ventricular arrhythmia, especially in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Degarelix and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes before starting and periodically afterward, particularly in patients with other QT risk factors. Consider alternatives if QTc becomes significantly prolonged.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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