Drug interactions
Degarelix + Propafenone
Severity: Moderate
Degarelix and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and propafenone also affects cardiac conduction. Combined use may raise the risk of ventricular arrhythmia, especially in older patients with cardiac disease.
What this interaction means in plain words
Degarelix and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with degarelix effects arising from androgen suppression.
What to do
Weigh the benefit against the arrhythmic risk before combining. Obtain a baseline ECG, correct electrolytes, and monitor the QTc periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Propafenone?
MediHelp rates the interaction as moderate. Degarelix and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and propafenone also affects cardiac conduction. Combined use may raise the risk of ventricular arrhythmia, especially in older patients with cardiac disease.
How serious is the interaction between Degarelix and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Weigh the benefit against the arrhythmic risk before combining. Obtain a baseline ECG, correct electrolytes, and monitor the QTc periodically.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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