Drug interactions
Degarelix + Quinidine
Severity: Major
Degarelix and Quinidine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy including degarelix can prolong the QT interval, and quinidine strongly prolongs it as well. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Degarelix and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Degarelix belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation (pharmacodynamic).
What to do
Evaluate whether the benefit outweighs the risk and avoid if an alternative exists. If used, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Degarelix Ferring 80 mg Powder and solvent for solution for injection - SmPC sections 4.3/4.5 (names the partner; "f degarelix with medicinal products known to prolong the QTc interval or medicinal products able to induce torsades de pointes such as class IA (e.g. quinidine,") — electronic medicines compendium (UK SmPC)
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Quinidine?
MediHelp rates the interaction as major. Degarelix and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation therapy including degarelix can prolong the QT interval, and quinidine strongly prolongs it as well. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Degarelix and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Evaluate whether the benefit outweighs the risk and avoid if an alternative exists. If used, monitor ECG and electrolytes.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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