Drug interactions
Delavirdine + Ethinyl estradiol-drospirenone
Severity: Moderate
Delavirdine and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delavirdine is a CYP3A4 inhibitor and can increase concentrations of ethinyl estradiol and drospirenone. Increased drospirenone exposure raises the risk of hyperkalemia and hormonal adverse effects.
What this interaction means in plain words
Delavirdine and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Delavirdine inhibits CYP3A4, reducing hepatic and intestinal metabolism of the contraceptive components.
What to do
Monitor serum potassium and hormonal adverse effects, particularly with renal impairment or other potassium-raising drugs. Consider an alternative contraceptive if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Delavirdine with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Delavirdine and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Delavirdine is a CYP3A4 inhibitor and can increase concentrations of ethinyl estradiol and drospirenone. Increased drospirenone exposure raises the risk of hyperkalemia and hormonal adverse effects.
How serious is the interaction between Delavirdine and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and hormonal adverse effects, particularly with renal impairment or other potassium-raising drugs. Consider an alternative contraceptive if tolerability is poor.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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