Drug interactions
Delavirdine + Ribociclib
Severity: Major
Delavirdine and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delavirdine is a potent CYP3A4 inhibitor and is itself metabolized by CYP3A4 and CYP2D6. Delavirdine would increase ribociclib exposure and QT prolongation risk, while ribociclib may modestly raise delavirdine levels. Strong CYP3A4 inhibitors should be avoided with ribociclib.
What this interaction means in plain words
Delavirdine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mutual CYP3A4 inhibition, chiefly delavirdine raising ribociclib levels.
What to do
Avoid the combination; use another antiretroviral. If unavoidable, reduce ribociclib dose per labeling and monitor ECG and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Delavirdine and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Delavirdine with Ribociclib?
MediHelp rates the interaction as major. Delavirdine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Delavirdine is a potent CYP3A4 inhibitor and is itself metabolized by CYP3A4 and CYP2D6. Delavirdine would increase ribociclib exposure and QT prolongation risk, while ribociclib may modestly raise delavirdine levels. Strong CYP3A4 inhibitors should be avoided with ribociclib.
How serious is the interaction between Delavirdine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use another antiretroviral. If unavoidable, reduce ribociclib dose per labeling and monitor ECG and blood counts.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
