Drug interactions
Demeclocycline + Ethinyl estradiol-drospirenone
Severity: Minor
Demeclocycline and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline antibiotics have been theorised to lower oral contraceptive effectiveness by disrupting gut bacteria that recycle estrogen. Controlled pharmacokinetic data show little or no meaningful drop in hormone levels, and contraceptive failure is rarely reported.
What this interaction means in plain words
Demeclocycline and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed reduction of enterohepatic recirculation of ethinyl estradiol through altered intestinal flora, which is not well supported by pharmacokinetic data.
What to do
No routine additional contraception is needed; counsel the patient to report vomiting or severe diarrhea, which would warrant backup contraception.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Demeclocycline with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Demeclocycline and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline antibiotics have been theorised to lower oral contraceptive effectiveness by disrupting gut bacteria that recycle estrogen. Controlled pharmacokinetic data show little or no meaningful drop in hormone levels, and contraceptive failure is rarely reported.
How serious is the interaction between Demeclocycline and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine additional contraception is needed; counsel the patient to report vomiting or severe diarrhea, which would warrant backup contraception.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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