Drug interactions
Dengue vaccine + Denosumab
Severity: Moderate
Dengue vaccine and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine. Immunosuppression could reduce the vaccine response and may permit uncontrolled replication of the vaccine virus. Denosumab is not a classic broad immunosuppressant, so the evidence is theoretical.
What this interaction means in plain words
Dengue vaccine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduction of immune response to a live attenuated vaccine; denosumab immune effects via RANKL inhibition are not well characterized.
What to do
Complete vaccination, where feasible, before a denosumab dose is due, and review the vaccine indication in patients who are otherwise immunocompromised. Monitor for vaccine-related infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Dengue vaccine with Denosumab?
MediHelp rates the interaction as moderate. Dengue vaccine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dengue vaccine is a live attenuated vaccine. Immunosuppression could reduce the vaccine response and may permit uncontrolled replication of the vaccine virus. Denosumab is not a classic broad immunosuppressant, so the evidence is theoretical.
How serious is the interaction between Dengue vaccine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination, where feasible, before a denosumab dose is due, and review the vaccine indication in patients who are otherwise immunocompromised. Monitor for vaccine-related infection.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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