Drug interactions
Dengue vaccine + Mycophenolate mofetil
Severity: Major
Dengue vaccine and Mycophenolate mofetil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate suppresses T- and B-lymphocyte proliferation and may blunt the antibody response to dengue vaccination. The dengue vaccine is a live attenuated product, so immunosuppressed patients also face a theoretical risk of vaccine-related infection. Protection may therefore be incomplete and the vaccine may be unsafe.
What this interaction means in plain words
Dengue vaccine and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism: inhibition of lymphocyte proliferation reduces vaccine immunogenicity, and live vaccine replication is less well controlled.
What to do
Avoid giving the live dengue vaccine to patients on mycophenolate at immunosuppressive doses; consult the product label and the transplant or specialist team. If vaccination is essential, consider timing it before immunosuppression begins.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as major. Dengue vaccine and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mycophenolate suppresses T- and B-lymphocyte proliferation and may blunt the antibody response to dengue vaccination. The dengue vaccine is a live attenuated product, so immunosuppressed patients also face a theoretical risk of vaccine-related infection. Protection may therefore be incomplete and the vaccine may be unsafe.
How serious is the interaction between Dengue vaccine and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live dengue vaccine to patients on mycophenolate at immunosuppressive doses; consult the product label and the transplant or specialist team. If vaccination is essential, consider timing it before immunosuppression begins.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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