Drug interactions
Dengue vaccine + Oxaliplatin
Severity: Major
Dengue vaccine and Oxaliplatin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and cytotoxic chemotherapy weakens the immune response and may permit vaccine virus replication. This can reduce vaccine effectiveness and increase the risk of vaccine-related infection.
What this interaction means in plain words
Dengue vaccine and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs vaccine response and permits replication of live attenuated virus.
What to do
Avoid live vaccines during chemotherapy and give them well before starting treatment or after immune recovery as advised by the specialist team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Oxaliplatin 5 mg/ml concentrate for solution for infusion - SmPC sections 4.3/4.5 (class statement: live or live attenuated vaccines; "Vaccination with live or live attenuated vaccines should be avoided in patients receiving oxaliplatin (see section 4.4).") — electronic medicines compendium (UK SmPC)
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Oxaliplatin?
MediHelp rates the interaction as major. Dengue vaccine and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and cytotoxic chemotherapy weakens the immune response and may permit vaccine virus replication. This can reduce vaccine effectiveness and increase the risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and give them well before starting treatment or after immune recovery as advised by the specialist team.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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