Drug interactions
Dengue vaccine + Ribociclib
Severity: Moderate
Dengue vaccine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine. Ribociclib causes neutropenia and may blunt immune responses, so vaccine response may be reduced and replication of the live virus could be less well controlled.
What this interaction means in plain words
Dengue vaccine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myelosuppressive and antiproliferative effects of ribociclib may impair immune response to a live attenuated vaccine.
What to do
Avoid giving the live vaccine during active ribociclib therapy with neutropenia; if vaccination is needed, check neutrophil count and consult oncology about timing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Ribociclib?
MediHelp rates the interaction as moderate. Dengue vaccine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dengue vaccine is a live attenuated vaccine. Ribociclib causes neutropenia and may blunt immune responses, so vaccine response may be reduced and replication of the live virus could be less well controlled.
How serious is the interaction between Dengue vaccine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live vaccine during active ribociclib therapy with neutropenia; if vaccination is needed, check neutrophil count and consult oncology about timing.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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