Drug interactions
Dengue vaccine + Tacrolimus
Severity: Major
Dengue vaccine and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and tacrolimus-induced immunosuppression may blunt the vaccine response. It also raises the risk of vaccine-strain disease in immunosuppressed patients.
What this interaction means in plain words
Dengue vaccine and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Tacrolimus suppresses T-cell function, reducing vaccine immunogenicity and impairing control of live vaccine virus.
What to do
Avoid live dengue vaccine in patients on tacrolimus; consider vaccination before immunosuppression when feasible and follow local guidance on timing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Tacrolimus?
MediHelp rates the interaction as major. Dengue vaccine and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and tacrolimus-induced immunosuppression may blunt the vaccine response. It also raises the risk of vaccine-strain disease in immunosuppressed patients.
How serious is the interaction between Dengue vaccine and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine in patients on tacrolimus; consider vaccination before immunosuppression when feasible and follow local guidance on timing.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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