Drug interactions
Denosumab + Doxorubicin liposomal
Severity: Moderate
Denosumab and Doxorubicin liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liposomal doxorubicin causes myelosuppression and immune compromise, and denosumab labeling warns about serious infections in patients with impaired immunity. Together the infection risk may be higher. No specific pharmacokinetic interaction is established.
What this interaction means in plain words
Denosumab and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on infection risk through chemotherapy-induced myelosuppression and possible immune modulation by denosumab.
What to do
Monitor blood counts and clinical signs of infection during co-treatment. Treat infections promptly and follow standard neutropenia precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Doxorubicin liposomal?
MediHelp rates the interaction as moderate. Denosumab and Doxorubicin liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liposomal doxorubicin causes myelosuppression and immune compromise, and denosumab labeling warns about serious infections in patients with impaired immunity. Together the infection risk may be higher. No specific pharmacokinetic interaction is established.
How serious is the interaction between Denosumab and Doxorubicin liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical signs of infection during co-treatment. Treat infections promptly and follow standard neutropenia precautions.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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