Drug interactions
Denosumab + Etoposide
Severity: Moderate
Denosumab and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab labeling warns of serious infections in patients with impaired immunity. Etoposide causes myelosuppression, which adds to infection risk.
What this interaction means in plain words
Denosumab and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Etoposide belongs to Oncology.
Why it happens
Additive infection risk: denosumab alters RANKL-mediated immune signalling and etoposide suppresses bone marrow function.
What to do
Monitor blood counts and watch for infection. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Denosumab with Etoposide?
MediHelp rates the interaction as moderate. Denosumab and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling warns of serious infections in patients with impaired immunity. Etoposide causes myelosuppression, which adds to infection risk.
How serious is the interaction between Denosumab and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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