Drug interactions
Denosumab + Hydrocortisone
Severity: Moderate
Denosumab and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab carries a risk of serious infections, including skin infection, and systemic corticosteroids add immunosuppression. Combined use may increase the risk or severity of infection, and hypocalcemia is a separate concern in some patients.
What this interaction means in plain words
Denosumab and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Additive immunosuppressive effect.
What to do
Monitor for signs of infection and treat promptly. Ensure calcium and vitamin D adequacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Hydrocortisone?
MediHelp rates the interaction as moderate. Denosumab and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab carries a risk of serious infections, including skin infection, and systemic corticosteroids add immunosuppression. Combined use may increase the risk or severity of infection, and hypocalcemia is a separate concern in some patients.
How serious is the interaction between Denosumab and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and treat promptly. Ensure calcium and vitamin D adequacy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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