Drug interactions
Denosumab + Ibritumomab tiuxetan
Severity: Moderate
Denosumab and Ibritumomab tiuxetan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibritumomab tiuxetan delivers radiation to B-cells and causes prolonged, severe cytopenias and immunosuppression. Adding denosumab, which carries a warning for serious infections, may add to infection risk. The combination is not well studied.
What this interaction means in plain words
Denosumab and Ibritumomab tiuxetan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive infection risk from radioimmunotherapy-induced myelosuppression and B-cell depletion plus possible immune effects of denosumab.
What to do
Monitor blood counts regularly and watch for infection until counts recover. Treat febrile episodes promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Ibritumomab tiuxetan?
MediHelp rates the interaction as moderate. Denosumab and Ibritumomab tiuxetan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibritumomab tiuxetan delivers radiation to B-cells and causes prolonged, severe cytopenias and immunosuppression. Adding denosumab, which carries a warning for serious infections, may add to infection risk. The combination is not well studied.
How serious is the interaction between Denosumab and Ibritumomab tiuxetan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and watch for infection until counts recover. Treat febrile episodes promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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