Drug interactions
Denosumab + Idarubicin
Severity: Moderate
Denosumab and Idarubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idarubicin causes profound myelosuppression, and denosumab has been linked to serious infections including skin infections. Together they may raise infection risk in an already immunocompromised patient.
What this interaction means in plain words
Denosumab and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Idarubicin belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: anthracycline-induced bone marrow suppression combined with RANKL inhibition affecting immune function.
What to do
Monitor blood counts and watch for infection signs during neutropenic periods. Start empirical treatment promptly for febrile episodes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Frequently asked questions
Can I take Denosumab with Idarubicin?
MediHelp rates the interaction as moderate. Denosumab and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idarubicin causes profound myelosuppression, and denosumab has been linked to serious infections including skin infections. Together they may raise infection risk in an already immunocompromised patient.
How serious is the interaction between Denosumab and Idarubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection signs during neutropenic periods. Start empirical treatment promptly for febrile episodes.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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