Drug interactions
Denosumab + Irinotecan liposomal
Severity: Moderate
Denosumab and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liposomal irinotecan commonly causes neutropenia and diarrhea, which raise infection risk. Denosumab labeling warns of serious infections in patients with impaired immunity, so the risks may be additive.
What this interaction means in plain words
Denosumab and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive infection risk from chemotherapy-induced neutropenia and possible immune effects of denosumab.
What to do
Monitor neutrophil counts and clinical signs of infection. Manage neutropenic fever per standard protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Denosumab and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liposomal irinotecan commonly causes neutropenia and diarrhea, which raise infection risk. Denosumab labeling warns of serious infections in patients with impaired immunity, so the risks may be additive.
How serious is the interaction between Denosumab and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and clinical signs of infection. Manage neutropenic fever per standard protocols.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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