Drug interactions
Denosumab + Mycophenolate
Severity: Moderate
Denosumab and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate suppresses lymphocyte proliferation and raises infection risk. Denosumab labeling cautions about serious infections in patients with impaired immunity, so the combination may increase risk. This is common in transplant recipients treated for bone loss.
What this interaction means in plain words
Denosumab and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from inhibition of lymphocyte purine synthesis and possible immune effects of denosumab.
What to do
Monitor for infection, including urinary and skin infections, and ensure calcium and vitamin D are replete. Report fever or new symptoms early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Mycophenolate?
MediHelp rates the interaction as moderate. Denosumab and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate suppresses lymphocyte proliferation and raises infection risk. Denosumab labeling cautions about serious infections in patients with impaired immunity, so the combination may increase risk. This is common in transplant recipients treated for bone loss.
How serious is the interaction between Denosumab and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection, including urinary and skin infections, and ensure calcium and vitamin D are replete. Report fever or new symptoms early.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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