Drug interactions
Denosumab + Ofatumumab sc
Severity: Moderate
Denosumab and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Subcutaneous ofatumumab depletes B-cells and may impair immune defenses. Combining it with denosumab, which has a labeled infection warning, may add to infection risk. Clinical data on the combination are limited.
What this interaction means in plain words
Denosumab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive infection risk from B-cell depletion and possible immune effects of denosumab.
What to do
Monitor for infection and review immunoglobulin levels if infections recur. Treat infections early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Ofatumumab sc?
MediHelp rates the interaction as moderate. Denosumab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Subcutaneous ofatumumab depletes B-cells and may impair immune defenses. Combining it with denosumab, which has a labeled infection warning, may add to infection risk. Clinical data on the combination are limited.
How serious is the interaction between Denosumab and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and review immunoglobulin levels if infections recur. Treat infections early.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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