Drug interactions
Denosumab + Paclitaxel protein bound
Severity: Moderate
Denosumab and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nab-paclitaxel frequently causes neutropenia and raises infection risk. Denosumab labeling warns of serious infections in immunocompromised patients, so the effects may be additive.
What this interaction means in plain words
Denosumab and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive infection risk from taxane-induced myelosuppression and possible immune effects of denosumab.
What to do
Monitor neutrophil counts before each cycle and watch for infection. Manage neutropenia per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Denosumab and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nab-paclitaxel frequently causes neutropenia and raises infection risk. Denosumab labeling warns of serious infections in immunocompromised patients, so the effects may be additive.
How serious is the interaction between Denosumab and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts before each cycle and watch for infection. Manage neutropenia per protocol.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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