Drug interactions
Denosumab + Rituximab-hyaluronidase
Severity: Moderate
Denosumab and Rituximab-hyaluronidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B-cells, causing hypogammaglobulinemia and a higher risk of infection, including hepatitis B reactivation. Denosumab labeling warns of serious infections in immunocompromised patients, so the risks may add together.
What this interaction means in plain words
Denosumab and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive infection risk from CD20-mediated B-cell depletion and possible immune effects of denosumab.
What to do
Monitor for infection and screen for hepatitis B before rituximab. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Denosumab and Rituximab-hyaluronidase, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Rituximab-hyaluronidase?
MediHelp rates the interaction as moderate. Denosumab and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab depletes B-cells, causing hypogammaglobulinemia and a higher risk of infection, including hepatitis B reactivation. Denosumab labeling warns of serious infections in immunocompromised patients, so the risks may add together.
How serious is the interaction between Denosumab and Rituximab-hyaluronidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and screen for hepatitis B before rituximab. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
