Drug interactions
Denosumab + Thiotepa
Severity: Moderate
Denosumab and Thiotepa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiotepa is an alkylating agent that causes severe myelosuppression, particularly at conditioning doses. Denosumab labeling warns of serious infections in immunocompromised patients, so infection risk may be higher.
What this interaction means in plain words
Denosumab and Thiotepa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Thiotepa belongs to Oncology.
Why it happens
Additive infection risk from alkylator-induced myelosuppression and possible immune effects of denosumab.
What to do
Monitor blood counts and watch for infection until recovery. Treat fever promptly with empiric therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Denosumab with Thiotepa?
MediHelp rates the interaction as moderate. Denosumab and Thiotepa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiotepa is an alkylating agent that causes severe myelosuppression, particularly at conditioning doses. Denosumab labeling warns of serious infections in immunocompromised patients, so infection risk may be higher.
How serious is the interaction between Denosumab and Thiotepa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection until recovery. Treat fever promptly with empiric therapy.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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