Drug interactions
Desflurane + Dextromoramide
Severity: Moderate
Desflurane and Dextromoramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic that adds to the CNS and respiratory depression of desflurane and lowers the anesthetic concentration needed. Excess dosing can cause marked respiratory depression, hypotension and delayed emergence.
What this interaction means in plain words
Desflurane and Dextromoramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression via mu-opioid agonism and anesthetic action.
What to do
Reduce desflurane requirements and titrate both agents to effect. Monitor ventilation and oxygen saturation and have naloxone available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Dextromoramide?
MediHelp rates the interaction as moderate. Desflurane and Dextromoramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromoramide is a potent opioid analgesic that adds to the CNS and respiratory depression of desflurane and lowers the anesthetic concentration needed. Excess dosing can cause marked respiratory depression, hypotension and delayed emergence.
How serious is the interaction between Desflurane and Dextromoramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce desflurane requirements and titrate both agents to effect. Monitor ventilation and oxygen saturation and have naloxone available.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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