Drug interactions
Desflurane + Esketamine intranasal
Severity: Moderate
Desflurane and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation and can raise blood pressure, while desflurane is a potent CNS depressant. Together they may deepen sedation and cause hemodynamic variability.
What this interaction means in plain words
Desflurane and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from NMDA antagonism and volatile anesthetic action, with opposing hemodynamic effects.
What to do
Tell the anesthesia team about recent esketamine dosing. Monitor blood pressure and sedation depth and titrate the anesthetic accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Esketamine intranasal?
MediHelp rates the interaction as moderate. Desflurane and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation and can raise blood pressure, while desflurane is a potent CNS depressant. Together they may deepen sedation and cause hemodynamic variability.
How serious is the interaction between Desflurane and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent esketamine dosing. Monitor blood pressure and sedation depth and titrate the anesthetic accordingly.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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