Drug interactions
Desflurane + Fexinidazole
Severity: Major
Desflurane and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and its labeling advises avoiding other QT-prolonging drugs. Desflurane may add to this effect and raise the risk of torsades de pointes.
What this interaction means in plain words
Desflurane and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and consider an anesthetic technique with less QT effect, such as propofol-based total intravenous anesthesia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Fexinidazole?
MediHelp rates the interaction as major. Desflurane and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval, and its labeling advises avoiding other QT-prolonging drugs. Desflurane may add to this effect and raise the risk of torsades de pointes.
How serious is the interaction between Desflurane and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and consider an anesthetic technique with less QT effect, such as propofol-based total intravenous anesthesia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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