Drug interactions
Desflurane + Levorphanol
Severity: Moderate
Desflurane and Levorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid that reduces the anesthetic requirement of desflurane and adds to its respiratory and CNS depression. Hypotension, bradycardia and delayed emergence may occur.
What this interaction means in plain words
Desflurane and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression, with opioid reduction of minimum alveolar concentration.
What to do
Reduce the desflurane concentration according to depth-of-anesthesia monitoring and monitor ventilation and hemodynamics. Provide postoperative respiratory monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Levorphanol?
MediHelp rates the interaction as moderate. Desflurane and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levorphanol is a potent opioid that reduces the anesthetic requirement of desflurane and adds to its respiratory and CNS depression. Hypotension, bradycardia and delayed emergence may occur.
How serious is the interaction between Desflurane and Levorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the desflurane concentration according to depth-of-anesthesia monitoring and monitor ventilation and hemodynamics. Provide postoperative respiratory monitoring.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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