Drug interactions
Desflurane + Lormetazepam
Severity: Moderate
Desflurane and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a hypnotic benzodiazepine that adds to the sedative and respiratory depressant effects of desflurane. Deeper sedation and slower emergence may result.
What this interaction means in plain words
Desflurane and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A receptor potentiation.
What to do
Titrate desflurane to depth-of-anesthesia monitoring and monitor respiratory function. Allow extra time for recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Lormetazepam?
MediHelp rates the interaction as moderate. Desflurane and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a hypnotic benzodiazepine that adds to the sedative and respiratory depressant effects of desflurane. Deeper sedation and slower emergence may result.
How serious is the interaction between Desflurane and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to depth-of-anesthesia monitoring and monitor respiratory function. Allow extra time for recovery.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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