Drug interactions
Desflurane + Loxapine inhaled
Severity: Moderate
Desflurane and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and it is absorbed systemically. Combined with desflurane, sedation may be increased and airway reactivity may be a concern.
What this interaction means in plain words
Desflurane and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine and serotonin antagonism with sedative antihistaminic effects, plus airway reactivity.
What to do
Monitor airway and oxygenation closely and have bronchodilators available. Titrate desflurane to depth-of-anesthesia monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Loxapine inhaled?
MediHelp rates the interaction as moderate. Desflurane and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine causes sedation and can cause bronchospasm, and it is absorbed systemically. Combined with desflurane, sedation may be increased and airway reactivity may be a concern.
How serious is the interaction between Desflurane and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor airway and oxygenation closely and have bronchodilators available. Titrate desflurane to depth-of-anesthesia monitoring.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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