Drug interactions
Desflurane + Metoclopramide intranasal
Severity: Minor
Desflurane and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has CNS depressant and extrapyramidal effects that may add to the effects of general anesthetics. The interaction with a volatile anesthetic is not well defined, and the intranasal product is used for outpatient diabetic gastroparesis.
What this interaction means in plain words
Desflurane and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS effects; the mechanism is not firmly established.
What to do
Hold the intranasal dose on the day of surgery according to institutional fasting protocols. Monitor for sedation and movement disorders postoperatively.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desflurane and Metoclopramide intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Desflurane and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide has CNS depressant and extrapyramidal effects that may add to the effects of general anesthetics. The interaction with a volatile anesthetic is not well defined, and the intranasal product is used for outpatient diabetic gastroparesis.
How serious is the interaction between Desflurane and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold the intranasal dose on the day of surgery according to institutional fasting protocols. Monitor for sedation and movement disorders postoperatively.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
