Drug interactions
Desflurane + Octreotide
Severity: Moderate
Desflurane and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and desflurane may add to the effect on repolarization. The combination may modestly increase arrhythmia risk.
What this interaction means in plain words
Desflurane and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia.
What to do
Check baseline ECG and heart rate and correct electrolytes before anesthesia. Monitor the ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Octreotide
Frequently asked questions
Can I take Desflurane with Octreotide?
MediHelp rates the interaction as moderate. Desflurane and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and desflurane may add to the effect on repolarization. The combination may modestly increase arrhythmia risk.
How serious is the interaction between Desflurane and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and heart rate and correct electrolytes before anesthesia. Monitor the ECG perioperatively.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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