Drug interactions
Desflurane + Olanzapine
Severity: Moderate
Desflurane and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane can prolong the QT interval and olanzapine has a small QT effect, so perioperative arrhythmia risk may rise slightly. Additive sedation and hypotension may also occur.
What this interaction means in plain words
Desflurane and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Check baseline ECG and electrolytes before surgery and monitor ECG during anaesthesia. Avoid adding other QT-prolonging agents when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Olanzapine?
MediHelp rates the interaction as moderate. Desflurane and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane can prolong the QT interval and olanzapine has a small QT effect, so perioperative arrhythmia risk may rise slightly. Additive sedation and hypotension may also occur.
How serious is the interaction between Desflurane and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes before surgery and monitor ECG during anaesthesia. Avoid adding other QT-prolonging agents when possible.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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